Giants vs. Reds odds, prediction, line: 2022 MLB picks, Friday, May 27 best bets from proven baseball model

The San Francisco Giants and Cincinnati Reds begin a weekend set on Friday evening. The NL foes will square off at Great American Ball Park in Cincinnati with an early evening start. Friday’s game is the first matchup of the season between the Giants and Reds. San Francisco enters with a 24-19 record, with Cincinnati at 14-30 to begin the 2022 season.

First pitch is at 6:40 p.m. ET in Cincinnati. Caesars Sportsbook lists San Francisco as a -215 favorite on the money line (risk $215 to win $100), while the over-under, or total number of runs Vegas thinks will be scored, is eight in the latest Giants vs. Reds odds. Before making any Reds vs. Giants picks, you need to see the MLB predictions and betting advice from SportsLine’s advanced computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It’s on a 41-30 roll on top-rated MLB money-line picks through seven weeks, returning almost $600 for $100 players. Anyone following it has seen huge returns.

Now, the model has set its sights on Giants vs. Reds and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model’s picks. Now, here are several MLB odds and betting lines for Reds vs. Giants:

  • Giants vs. Reds money line: Giants -215, Reds +185
  • Giants vs. Reds over-under: 8 runs
  • Giants vs. Reds run line: Giants -1.5 (-120)
  • Giants vs. Red tickets: See tickets at StubHub
  • SF: The Giants are 11-8 in road games
  • CIN: The Reds are 7-11 in home games

Featured Game | Cincinnati Reds vs. San Francisco Giants

Why you should back the Giants

San Francisco has the better offensive numbers when compared to Cincinnati this season, but the Giants’ biggest edge comes in starting pitching on Friday. The Giants are projected to deploy veteran left-hander Carlos Rodon, who was an All-Star in 2021 while finishing in the top five in Cy Young voting. Rodon has allowed two runs or fewer in seven of his eight starts in 2022, and left-handed batters have a comically poor .074/.194/.074 slash line against him this season. 

Rodon also leads the National League in strikeout rate, and he has a sparkling 2.64 ERA in 32 starts since the beginning of the 2021 season. Over that sample, Rodon has generated 12.5 strikeouts and 2.7 walks per nine innings, and he also has a favorable matchup in Cincinnati. The Reds are below-average in the National League in runs scored, and Cincinnati has only 39 home runs. The Reds are also in the bottom tier of the league in batting average, on-base percentage and slugging percentage, with Cincinnati also posting a subpar 8.3 percent walk rate as a team.

Why you should back the Reds

After a disastrous start to the season, Cincinnati is beginning to right the ship. The Reds are 11-8 in the last 19 games, operating like a completely different club. That came to a head on Thursday afternoon when Cincinnati scored 20 runs in a blowout win over the Chicago Cubs, and the Reds generated 20 hits and seven walks in the game. The Reds have 74 doubles this season, a mark well above the NL average, and Cincinnati can perhaps take advantage of a scuffling Giants bullpen. 

San Francisco’s relievers have a 4.54 combined ERA this season, ranking in the bottom five of the National League, and the team’s bullpen has a dismal strikeout rate of only 7.69 batters per nine innings. On the run prevention side, the Giants are in the bottom five of the National League in both doubles (67) and triples (three), and Cincinnati, which hasn’t announced a starter as of Friday morning, has the advantage of playing in front of its home fans.

How to make Reds vs. Giants picks

SportsLine’s model is leaning over on the total, projecting 10 combined runs. It also says one side of the money line has all the value. You can only get the MLB model’s picks at SportsLine.

So who wins Giants vs. Reds? And which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.  

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