Tigers vs. Cardinals odds, line: 2021 MLB picks, August 25 predictions from proven computer model

The Detroit Tigers go for the two-game series sweep over the St. Louis Cardinals when they meet in an interleague matchup on Wednesday afternoon. The Cardinals (63-61), third in the National League Central, have lost three of four. The Tigers (61-66), third in the American League Central, have won three of four, including a series win over the Toronto Blue Jays this past weekend. The Tigers have won four straight games over the Cardinals.

First pitch from Busch Stadium is set for 1:15 p.m. ET. The Tigers lead the all-time series 35-24, including a 15-12 edge in games played at St. Louis. The Cardinals are a -125 favorite (risk $125 to win $100) on the money line in the latest Tigers vs. Cardinals odds from Caesars Sportsbook, while the over-under for total runs scored is 9.5. Before making any Cardinals vs. Tigers picks, check out the latest MLB predictions from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, is 166-137 on top-rated MLB money-line picks through 21 weeks in the 2021 season, returning well over $400. It also had a banner 2019 season, the league’s last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. Anyone following it has seen some huge returns.

Now, the model has dialed in on Tigers vs. Cardinals and revealed its predictions and best bets. You can visit SportsLine now to see its MLB picks. Here are the MLB odds and betting trends for Cardinals vs. Tigers:

  • Tigers vs. Cardinals money line: Detroit +115, St. Louis -125
  • Tigers vs. Cardinals run line: St. Louis -1.5 (+140)
  • Tigers vs. Cardinals over-under: 9.5 runs
  • DET: The Tigers are 4-0 in their last four interleague games against a left-handed starter
  • STL: The Cardinals are 7-3 in their last 10 games vs. a team with a losing record

Why you should back the Cardinals 

St. Louis is expected to start left-hander Jon Lester (4-6, 5.46 ERA). Lester will be making his fifth start with the Cardinals after being acquired from the Washington Nationals at the trade deadline. He made 16 starts for Washington. In his last start against the Milwaukee Brewers on Thursday, he allowed four earned runs on six hits in 4 1/3 innings of work. In his previous outing at Kansas City on Aug. 14, he picked up a 9-4 win, allowing just one earned run on seven hits in 7 2/3 innings. 

Offensively, first baseman Paul Goldschmidt has been red hot and had an 11-game hitting streak snapped on Tuesday night. He was 19-for-45 (.422) with seven doubles, one homer and eight RBIs during the streak. He had multi-hit performances in eight of those games, going 5-for-13 (.385) against the Pirates this past weekend and 6-for-13 (.462) in the series against the Brewers. In 12 career games against the Tigers, Goldschmidt is batting .286 with a double, two homers and five RBIs.

Why you should back the Tigers

Left-hander Tarik Skubal (8-11, 4.02 ERA) is expected to take the mound for Detroit. Skubal has pitched well of late and has won two of his last three starts, allowing just two runs in 17 2/3 innings. He is coming off a 3-1 loss to the Los Angeles Angels, allowing two earned runs on six hits in 6 2/3 innings. He pitched shutout ball in his previous two outings against Boston and Baltimore. 

Second baseman Jonathan Schoop has had a solid season at the plate for the Tigers. In 122 games, he is hitting .281 with 18 homers, 69 RBIs and 66 runs scored. Since Aug. 4, Schoop has had nine multi-hit games, including a 3-for-5 performance against the Los Angeles Angels on Thursday. He has fared well against Cardinals pitching throughout his career, batting .271 with two doubles, four homers and 12 RBIs in 15 games.

How to make Cardinals vs. Tigers picks

SportsLine’s model is leaning under on the total, as the simulations show both teams combining for 8.3 runs. It also says one side of the money line has the value. You can only get the pick at SportsLine.

So who wins Tigers vs. Cardinals? And which side of the money line has all the value? Visit SportsLine now to see which side of the Cardinals vs. Tigers spread to jump on Wednesday, all from the advanced model that has been profitable on MLB picks in 2021. 

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